Fluctuations in network dynamics: SMAR1 can trigger apoptosis
نویسندگان
چکیده
Md. Zubbair Malik, Md. Jahoor Alam, Romana Ishrat, Subhash M. Agarwal and R.K. Brojen Singh Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi-110025, India. College of Applied Medical Sciences, University of Hail, Hail-2440, Kingdom of Saudi Arabia. Bioinformatics Division, Institute of Cytology and Preventive Oncology, 1-7, Sector 39, Noida 201301, India. School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi-110067, India.
منابع مشابه
Control of apoptosis by SMAR1.
The nuclear matrix associated protein SMAR1 is sensitive to p53 and acts as a stress inducer as well as a regulator in the p53 regulatory network. Depending on the amount of stress SMAR1 stimulates, it can drive the p53 dynamics in the system to various dynamical states which correspond to various cellular states. The behavior of p53 in these dynamical states is found to be multifractal, due to...
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How tumour suppressor p53 bifurcates cell cycle arrest and apoptosis and executes these distinct pathways is not clearly understood. We show that BAX and PUMA promoters harbour an identical MAR element and are transcriptional targets of SMAR1. On mild DNA damage, SMAR1 selectively represses BAX and PUMA through binding to the MAR independently of inducing p53 deacetylation through HDAC1. This g...
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Prostaglandins are anticancer agents known to inhibit tumor cell proliferation both in vitro and in vivo by affecting the mRNA stability. Here we report that a MAR-binding protein SMAR1 is a target of Prostaglandin A2 (PGA2) induced growth arrest. We identify a regulatory mechanism leading to stabilization of SMAR1 transcript. Our results show that a minor stem and loop structure present in the...
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